Yes, this is no problem. For GUI and HUD elements, usually you will use a CanvasLayer, which will draw above the 3D screen and you can use this for health bars and ammo and stuff that doesn't move. You can also combine 2D and 3D in other ways using viewports, for example if your game has a 3D smartphone in it and you want to control a 2D interface on the phone, you can do that too (or 3D in 3D, like security camera on a TV, etc.).