Personally, I don't care what people do with my game. I mean, I can understand wanting to protect your investment, but we see over time that these protection measures usually just cause hassle to legitimate customers and the pirates easily hack the code in short order and post the game online for free anyhow.
For example, there were older DVD based games that used a form of online DRM but years later this broke and caused the games not to work. Can't recall which game it was, I think Bioshock 2 had a problem like this where I actually had to go download a cracked exe just to play a game I paid for.
I've actually considered uploading my game (when I finish it) to pirate sites myself. I would rather more people play it, and I'm not sure there is a direct connection to sales (meaning the people that pay for media always pay, and pirates always pirate). There was an article once talking about how popularity on pirate sites actually increased sales, since more people were playing, making videos, posting online, and otherwise promoting the title. I could believe it.
In your case, I'd be interested to know what the risk factors are. Meaning, what exactly are you trying to protect against? The answer to this would make a difference. Do you want to stop people from stealing the textures or models and using it in another game? Users pirating? Cheaters?
I mean, I have heard about developers having their whole game ripped off (especially on mobile) where they might steal assets or decompile and reskin a game, or even just submit the same title with a different name. Usually you can work with Apple/Google and have these removed if you find them. The IP-thieves in these cases are usually in countries outside the US, so there probably isn't too much you can do legally to punish them, but it is a fair worry.